REACH Legislation

REACH is the European Regulation on Registration, Evaluation, Authorisation and Restriction of Chemicals. It entered into force in 2007, replacing the former legislative framework for chemicals in the EU.

On 4 February 2020, the REACH Committee (established under REACH, consisting of representatives of the Member States and the EU Commission) voted in favour of the European Commission’s proposal for a REACH restriction on diisocyanates. The Restriction was published on 4 August 2020 and came into force on 24 August 2023 after a transition period of three years.

The Restriction on Diisocyanates is available in all official EU languages here.

List of substances (please note that this list of Diisocyanates is not exhaustive):

Name EC / List no. CAS no.
2-methyl-m-phenylene diisocyanate 202-039-0 91-08-7
3,3′-dimethylbiphenyl-4,4′-diyl diisocyanate 202-112-7 91-97-4
4,4’-Methylenediphenyl diisocyanate 202-966-0 101-68-8
Hexamethylene diisocyanate 212-485-8 822-06-0
4-methyl-m-phenylene diisocyanate 209-544-5 584-84-9
4,4′-methylenedicyclohexyl diisocyanate 225-863-2 5124-30-1
m-tolylidene diisocyanate 247-722-4 26471-62-5
2,4,6-triisopropyl-m-phenylene diisocyanate 218-485-4 2162-73-4
2,2’-Methylenediphenyl diisocyanate 219-799-4 2536-05-2
1,3-bis(1-isocyanato-1-methylethyl)benzene 220-474-4 2778-42-9
1,5-naphthylene diisocyanate 221-641-4 3173-72-6
1,3-bis(isocyanatomethyl)benzene 222-852-4 3634-83-1
3-isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate 223-861-6 4098-71-9
2,4’-Methylenediphenyl diisocyanate 227-534-9 5873-54-1

Source: 

https://echa.europa.eu/de/substances-restricted-under-reach/-/dislist/details/0b0236e185347b62

Training levels

The Restriction specifies 3 different levels of training required for various uses of diisocyanates, 
the General Training as a minimum requirement and depending on the exposure an Intermediate Training and an Advanced Training. This matrix will help you to select the right training course.